Evolution teaches prediction

• Is Bioinformatics up to the data deluge?

• Sequence comparison: do we know what we do?

  • conservation of structure and function

• Structure prediction: where are we today?

• How to learn from the evolutionary odyssey?

  • secondary structure
  • transmembrane proteins
  • solvent accessibility

• Are 1D predictions useful?

  • sub-cellular localisation
  • whole genomes
  • 3D structure: threading
  • floppy regions

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